New study shows adding a prebiotic fiber blend to a puppy's diet supports growth and development and favorable digestive health

A healthy GI microbiome is essential for proper nutrient absorption, metabolism, and gut immunomodulation, which are crucial for the overall health and development of companion animals1,2. Probiotics, prebiotics, and postbiotics have all shown promising results in improving GI health in adult companion animals3,4,5. Given the importance of establishing a robust GI microbiome, researchers at Hill's Pet Nutrition have investigated the effects of a novel prebiotic blend on growing puppies in a recent study published in Frontiers in Veterinary Science6.

Prior research using this proprietary prebiotic blend resulted in positive effects on stool quality, pH, short-chain fatty acid (SCFA) production, and GI microbiome signatures in adult dogs and cats7,8. For the current study, 22 puppies between the ages of 4 and 10 months were fed a prefeed food for 2 weeks, then transitioned to the test food containing the prebiotic blend until they were 14 months old. The puppies showed normal growth and development throughout the study.

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Much like the adult dog study, the puppies had marked improvements in key parameters of GI health. Stool quality was improved and fecal short-chain fatty acids (SCFAs) were increased. Fecal SCFAs are important for maintaining intestinal homeostasis and supporting gut barrier function, which are important for proper nutrient absorption and metabolism. The puppies also showed an increase in serum immunoglobulin A levels suggesting an improved immune response9. Interleukin-17 (IL-17), an inflammatory cytokine, concentration decreased linearly over time and interleukin-18 (IL-18) trended towards linear decrease, which may indicate a reduction in inflammation over the course of the study. IL-7 is associated with inflammatory diseases, such as inflammatory bowel disease10, while IL-18 has been associated with intestinal inflammation in mice11. While these results are promising, more work needs to be done to evaluate the effects of fiber consumption on inflammatory markers in puppies.

Overall, this research contributes to the understanding of nutritional science concerning the GI health of puppies. As one of the first studies examining the impact of a prebiotic blend in puppy nutrition, this research offers insights for creating diets that provide superior nutrition for developing companion animals.

By: Renea Creech Senior Specialist, Scientific Communications Hill's Pet Nutrition

Source: DVM 360º
 

References

• Lyu Y, Su C, Verbrugghe A, Van de Wiele T, Martos Martinez-Caja A, Hesta M. Past, present, and future of gastrointestinal microbiota research in cats. Front Microbiol. (2020) 11:1661. doi: 10.3389/fmicb.2020.01661
• Sarkar A, Yoo JY, Valeria Ozorio Dutra S, Morgan KH, Groer M. The association between early-life gut microbiota and long-term health and diseases. J Clin Med. (2021) 10:459. doi: 10.3390/jcm10030459
  
  
• Wernimont SM, Radosevich J, Jackson MI, Ephraim E, Badri DV, MacLeay JM, et al. The effects of nutrition on the gastrointestinal microbiome of cats and dogs: impact on health and disease. Front Microbiol. (2020) 11:1266. doi: 10.3389/fmicb.2020.01266.
• Pilla R, Suchodolski JS. The gut microbiome of dogs and cats, and the influence of diet. Vet Clin North Am Small Anim Pract. (2021) 51:605–21. doi: 10.1016/j. Cvsm.2021.01.002
• Lee D, Goh TW, Kang MG, Choi HJ, Yeo SY, Yang J, et al. Perspectives and advances in probiotics and the gut microbiome in companion animals. J Anim Sci Technol. (2022) 64:197–217. doi: 10.5187/jast.2022.e8
• McGrath, A. P., Motsinger, L. A., Brejda, J., & Hancock, L. (2024). Prebiotic fiber blend supports growth and development and favorable digestive health in puppies. Frontiers in Veterinary Science, 11, 1409394.
• Fritsch DA, Jackson MI, Wernimont SM, Feld GK, Badri DV, Brejda JJ, et al. Adding a polyphenol-rich fiber bundle to food impacts the gastrointestinal microbiome and metabolome in dogs. Front Vet Sci. (2022) 9:1039032. doi: 10.3389/ fvets.2022.1039032
• Wernimont SM, Fritsch DA, Schiefelbein HM, Brejda JJ, Gross KL. Food with specialized dietary fiber sources improves clinical outcomes in adult cats with constipation or diarrhea. FASEB J. (2020) 34:1. doi: 10.1096/fasebj.2020.34.s1.09918
• Patel A, Jialal I. Biochemistry, immunoglobulin A In: StatPearls. Treasure Island, FL: StatPearls Publishing LLC (2024)
• Willis CR, Seamons A, Maxwell J, Treuting PM, Nelson L, Chen G, et al. Interleukin-7 receptor blockade suppresses adaptive and innate inflammatory responses in experimental colitis. J Inflamm. (2012) 9:39. doi: 10.1186/1476-9255-9-39
• Kanai T, Watanabe M, Okazawa A, Sato T, Yamazaki M, Okamoto S, et al. Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease. Gastroenterology. (2001) 121:875–88. doi: 10.1053/gast.2001.28021